It just occurred to me that my biggest problem is a lack of perspective, an inability to determine which problems are big and which are trivial.
My lack of perspective causes me tremendous difficulty in all areas of my life. It's probably the worst problem ever to face a human being.
In fact, my lack of perspective is probably going to result in the end of civilization as we know it, and possibly the destruction of the entire universe.
(I suppose the soundbite version of that, which come to think of it I probably got from Jack Mantis, is: "My tendency to exaggerate problems is the single most important issue facing humanity today.")