LSD

I always vaguely wondered how "lysergic acid diethylamide" got abbreviated as "LSD." I think I figured (or had been told) that the S came from "lySergic," but that didn't make much sense.

Turns out, according to Wikipedia, the acronym is from the German name: "Lysergsäure-diethylamid," where the S is for "säure."

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